ABSTRACT
The study was conducted in Babylon governorate on vaccinated person about (85) with or without previous infection as a test group, in comparison with (35) person recovering from Covid-19 which mentioned as positive (+ve) control with (30) healthy population as a negative (-ve) control groups. Different parameters were studied to evaluation of immunological status after receiving complete doses of different vaccine, low level of anti Sars-cov2 -IgM Ab of both vaccinated and control groups, while increased of Sars-cov2 -IgG in vaccinated population in comparison with control, at Mean ± SD (33.21 ± 16.06, 20.36 ± 14.0, 21.47 ± 13.77) in respective manner at P. Value < 0.01. There was a highly increased in IL-12, IL-15 and INF - y levels in comparison with control groups. The cytokines level among infected population after receiving vaccine were higher than non-infected person as well as in control groups. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.
ABSTRACT
By preventing viral membrane hemifusion between the host and viral cell cytoplasm, the interferon-induced transmembrane protein 3 (IFITM3) contributes significantly to the adaptive and innate immune response. Incidence and severity of influenza or other viral infections have been linked to single nucleotide polymorphisms (SNPs) in the gene IFITM3. Our goal was to examine how SNPs in the gene IFITM3 affected SARS-CoV-2 infection. The study's sampling took place on Covid-19, a subject patient in Babylon Governorate, between October 24, 2021 and November 1, 2022. There were Four single-nucleotide polymorphisms (SNPs) were genotyped in the 305 base-pair PCR results of the IFITM3 center advertiser locale around record start site (rs6598045), (rs7478728), (rs71452596), (rs7479267). Every one of these SNPs were in Hardy-Weinberg harmony (P.0.05) both in the Covid -19 and control gatherings. was found among three SNPs, rs7478728, rs71452596 and rs7479267. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.
ABSTRACT
Infection by the Covid-19 produces in people an illness of profoundly factor and erratic seriousness. The presence of continuous hereditary single nucleotide polymorphisms (SNPs) in the population could prompt a more prominent weakness to infections or an overstated provocative reaction. We concentrated on the relationship between SNP from AGTR1 gene and the seriousness of the infection created by the SARS-Cov-2 infection. Methods: 30 (18 of male and 12 of Female) Covid-19 patients with age range from 55-60 years were assembled in light of the seriousness of side effects. Results: one SNP rs5186 in AGTR1 gene were related with the seriousness of illness. Our results were showed that the rs5186 (C) allele in AGTR1 gene is associated with increased risk for Covid 19 based on OR value: homozygous allele CC has 2.5(0.7-8.5), allele C with allele frequency 20 more than control group, and with OR=2.5(1.5-5.9) with significant P values (P=0.03).